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Sensitivity to cisplatin in primary cell lines derived from human glioma correlates with levels of EGR-1 expression
Authors:Email author" target="_blank">Antonella?CalogeroEmail author  Antonio?Porcellini  Vincenza?Lombari  Cinzia?Fabbiano  Antonietta?Arcella  Massimo?Miscusi  Donatella?Ponti  Giuseppe?Ragona
Institution:(1) Department of Medical-surgical Science and Biotechnologies, University of Rome “Sapienza”, Corso della Repubblica 79, 04100 Latina, Italy;(2) University of Molise, 86100 Campobasso, Italy;(3) IRCCS Neuromed, 86077 Pozzilli, Italy
Abstract:

Background  

Less than 30% of malignant gliomas respond to adjuvant chemotherapy. Here, we have asked whether variations in the constitutive expression of early-growth response factor 1 (EGR-1) predicted acute cytotoxicity and clonogenic cell death in vitro, induced by six different chemotherapics.
Keywords:
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