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The miaA mutator phenotype of Escherichia coli K-12 requires recombination functions
Authors:Zhao J  Leung H E  Winkler M E
Affiliation:Department of Microbiology and Molecular Genetics, University of Texas-Houston Medical School, Houston, Texas 77030, USA.
Abstract:
miaA mutants, which contain A-37 instead of the ms(2)i(6)A-37 hypermodification in their tRNA, show a moderate mutator phenotype leading to increased GC-->TA transversion. We show that the miaA mutator phenotype is dependent on recombination functions similar to, but not exactly the same as, those required for translation stress-induced mutagenesis.
Keywords:
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