The miaA mutator phenotype of Escherichia coli K-12 requires recombination functions |
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Authors: | Zhao J Leung H E Winkler M E |
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Affiliation: | Department of Microbiology and Molecular Genetics, University of Texas-Houston Medical School, Houston, Texas 77030, USA. |
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Abstract: | ![]() miaA mutants, which contain A-37 instead of the ms(2)i(6)A-37 hypermodification in their tRNA, show a moderate mutator phenotype leading to increased GC-->TA transversion. We show that the miaA mutator phenotype is dependent on recombination functions similar to, but not exactly the same as, those required for translation stress-induced mutagenesis. |
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