DNA-mediated transfer of actinomycin D resistance into cultured mouse cells |
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| Authors: | H. G. Su rez, P. C. Nardeux,M. Barbich |
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| Affiliation: | H. G. Suárez, P. C. Nardeux,M. Barbich |
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| Abstract: | The transfer of high molecular weight (HMW) DNA isolated from Syrian hamster actinomycin D-resistant cells (C12TSV5/R) to sensitive A9 mouse cells, resulted in the growth in selective medium of transferent clones A9 ActR C11, C12 and C13). The resistant mouse cells have presumably acquired a gene(s) conferring actinomycin D resistance and express a 140-150 K surface glycoprotein, apparently involved in the drug resistance. |
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