Whole Blood Gene Expression Profiles of Patients with a Past Aneurysmal Subarachnoid Hemorrhage |
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| Authors: | Femke N. G. van ’t Hof Ynte M. Ruigrok Jelena Medic Bahram Sanjabi Pieter van der Vlies Gabriel J. E. Rinkel Jan H. Veldink |
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| Affiliation: | 1 Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands, ; 2 University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands, ; Heinrich-Heine University, GERMANY, |
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| Abstract: | ![]()
BackgroundThe pathogenesis of development and rupture of intracranial aneurysms (IA) is largely unknown. Also, screening for IA to prevent aneurysmal subarachnoid hemorrhage (aSAH) is inefficient, as disease markers are lacking. We investigated gene expression profiles in blood of previous aSAH patients, who are still at risk for future IA, aiming to gain insight into the pathogenesis of IA and aSAH, and to make a first step towards improvement of aSAH risk prediction.ConclusionsNo gene expression differences were present in blood of previous aSAH patients compared to controls, besides one differentially co-expressed gene network without a clear relevant biological function. Our findings suggest that gene expression profiles, as detected in blood of previous aSAH patients, do not reveal the pathogenesis of IA and aSAH, and cannot be used for aSAH risk prediction. |
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