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| 血管紧张素-(1-7)的舒血管效应 | |
| 作者姓名： | Zhi JM Chen RF Wang J Jiao XY Zhao RR |
| 作者单位： | 1. 上海第二医科大学生理学教研室,上海,200025 2. 第二军医大学卫生毒理学教研室,上海,200433 3. 山西医科大学生理学教研室,太原,030001 |
| 摘 要： | 实验采用兔外周动脉离体标本,在预收缩血管后,用血管紧张素angiotensin-(1-7),Ang-(1-7)]舒张血管,比较Ang-(1-7)对外周各血管床的舒张效应并分析其产生机制。结果显示：(1)Ang-(1-7)可剂量依赖性舒张血管,但舒张作用有所不同;(2)Ang-(1-7)的舒张作用在很大程度上依赖于内皮的NO系统;(3)Ang-(1-7)的舒张血管效应不通过AT1和AT2受体。上述结果提示：Ang-(1-7)可能作用于内皮上的非AT1和AT2受体,通过调节NO释放而起舒血管作用。 |
| 关 键 词： | 血管紧张素 血管舒张 受体 |
Comparative studies of vasodilating effects of angiotensin-(1-7) on the different vessels |
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| Zhi JM,Chen RF,Wang J,Jiao XY,Zhao RR.Comparative studies of vasodilating effects of angiotensin-(1-7) on the different vessels[J].Acta Physiologica Sinica,2004,56(6):730-734. | |
| Authors: | Zhi Jian-Ming Chen Rong-Fang Wang Jin Jiao Xiang-Ying Zhao Rong-Rui |
| Institution: | Department of Physiology, Shanghai Second Medical University, Shanghai 200025, China. zhjm169@sohu.com |
| Abstract: | The purpose of this study was to compare the vasodilating effects of angiotensin-(1-7) Ang-(1-7)] on the different vessels and to clarify its mechanisms by using relaxing responses of preconstricted vascular rings. The results showed: (1) Ang-(1-7) dose- dependently induced vasorelaxation in all the vessels studied. However, there is apparent heterogeneity in the responsiveness of vessels from different origin. (2) The Ang-(1-7)-induced vasorelaxation was endothelium dependent and largely mediated by NO system. (3) The vasodilator action of Ang-(1-7) was not mediated by AT1 or AT2 receptor subtypes. It is suggested that the Ang-(1-7)- induced vasorelaxation is endothelium dependent by some other unclarified angiotensin receptor subtypes and is largely mediated by NO system. |
| Keywords: | angiotensin vasorelaxation receptor |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ | |