The level of pancreatic PLA2 receptor is closely associated with the proliferative state of rat uterine stromal cells |
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| Authors: | Christian Tessier Gian-Paolo Rossini Jean-François Pageaux Hélène Cohen Michel Lagarde Christian Laugier Jean-Michel Fayard |
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| Institution: | aLaboratoire de Physiologie-Pharmacodynamie, INSERM U.352, INSA 406, 69621 Villeurbanne, France;bDipartimento di Scienze Biomediche, Universita Degli Studi di Modena, 41100 Modena, Italy;cLaboratoire de Chimie Biologique, INSERM U.352, INSA 406, 69621 Villeurbanne, France |
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| Abstract: | Rat uterine stromal cells (UIII) express pancreatic type PLA2 (PLA2-I) receptor and internalize the enzyme bound to receptors. Here, we investigate the proliferating effect and alterations in binding of PLA2-I. There is a dramatic decline in PLA2-I binding in UIII cells as they progress from a nonconfluent proliferating state (40,000 sites/cell) to a confluent state (1300 sites/cell). Intracellular concentration of PLA2-I changed with the alteration in binding, suggesting that regulation in the PLA2 binding capacity may have important implications in growth control mechanisms. |
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| Keywords: | Pancreatic phospolipase A2 PLA2 receptor Proliferation Uterine stromal cell line Rat |
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