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Human articular chondrocytes express 15-lipoxygenase-1 and -2: potential role in osteoarthritis
Authors:Nadir Chabane  Nadia Zayed  Mohamed Benderdour  Johanne Martel-Pelletier  Jean-Pierre Pelletier  Nicolas Duval  Hassan Fahmi
Affiliation:1. Department of Medicine, The Johns Hopkins Hospital, The Johns Hopkins University, 600 N Wolfe Street, Baltimore, MD, 21287, USA
6. Division of Rheumatology, The Johns Hopkins University, 5200 Eastern Avenue, Suite 4100, Baltimore, MD, 21224, USA
2. Department of Epidemiology, The Johns Hopkins Hospital, The Johns Hopkins University, 600 N Wolfe Street, Baltimore, MD, 21287, USA
3. Department of Radiological Sciences, University of California at Irvine, Medical Sciences Building, Irvine, CA, 92697, USA
4. Department of Radiology, The Johns Hopkins Hospital, The Johns Hopkins University, 600 N Wolfe Street, Baltimore, MD, 21287, USA
5. Department of Biostatistics, F-600, Health Sciences Building, University of Washington, 1705 NE Pacific Street, Seattle, WA, 98195, USA
Abstract:

Introduction

Although cardiovascular morbidity and mortality are increased in rheumatoid arthritis, little is known about the burden of subclinical coronary atherosclerosis in these patients.

Methods

Using computed tomography, coronary artery calcification was measured in 195 men and women with rheumatoid arthritis aged 45 to 84 years without clinical cardiovascular disease and compared with 1,073 controls without rheumatoid arthritis enrolled in the Baltimore cohort of the Multi-Ethnic Study of Atherosclerosis.

Results

The prevalence of coronary calcification (Agatston score > 0) was significantly higher in men, but not women, with rheumatoid arthritis after adjusting for sociodemographic and cardiovascular risk factors (prevalence ratio = 1.19; P = 0.012). Among participants with prevalent calcification, those with rheumatoid arthritis had adjusted mean Agatston scores 53 units higher than controls (P = 0.002); a difference greater for men than women (P for interaction = 0.017). In all analyses, serum IL-6 attenuated the association between rheumatoid arthritis and coronary calcification, suggesting its role as a potential mediator of enhanced atherosclerosis. Notably, increasing severity of rheumatoid arthritis was associated with a higher prevalence and extent of coronary calcification among both men and women with rheumatoid arthritis, and for all age categories. The largest percentage difference in coronary arterial calcification between rheumatoid arthritis patients and their nonrheumatoid arthritis counterparts was observed in the youngest age category.

Conclusions

Increasing rheumatoid arthritis disease severity was associated with a higher prevalence and greater extent of coronary artery calcification, potentially mediated through an atherogenic effect of chronic systemic inflammation. Gender and age differences in association with coronary calcification suggest that preventive measures should be emphasized in men with rheumatoid arthritis, and considered even in younger rheumatoid arthritis patients with low levels of traditional cardiovascular risk factors.
Keywords:
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