Effects of Modulation of the Activity of the Autonomic Nervous System on the Efficiency of Liposomal Sandostatin in the Treatment of Experimental Pancreatitis

We measured the concentrations of the main gastrointestinal hormones (gastrin, somatostatin, insulin, and glucagon) in the blood serum of control rats and rats with experimental chronic pancreatitis (EChP). The composition of gastrointestinal hormones in the blood of animals with EChP was shown to change considerably; this was manifested in increases in the contents of gastrin and glucagon and a dramatic drop in the insulin concentration. Injections of the liposomal form of sandostatin exerted a normalizing effect on the secretory activity of the gastroenteropancreatic axis. The liposomal sandostatin-induced normalization of the composition of gastrointestinal hormones was more significant in animals with EChP, which were bilaterally vagotomized; pharmacological desympathization did not exert a considerable effect on the curative activity of sandostatin.