Activating and inhibiting connections in biological network dynamics |
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| Authors: | Daniel McDonald Laura Waterbury Rob Knight M D Betterton |
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| Affiliation: | (1) Department of Computer Science, University of Colorado, 430 UCB, Boulder, CO 80309, USA;(2) Department of Applied Mathematics, University of Colorado, 526 UCB Boulder, CO 80309, USA;(3) Department of Chemistry and Biochemistry, University of Colorado, 215 UCB, Boulder, CO 80309, USA;(4) Department of Physics, University of Colorado, 390 UCB, Boulder, CO 80309, USA |
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| Abstract: | ![]()
Background Many studies of biochemical networks have analyzed network topology. Such work has suggested that specific types of network wiring may increase network robustness and therefore confer a selective advantage. However, knowledge of network topology does not allow one to predict network dynamical behavior – for example, whether deleting a protein from a signaling network would maintain the network's dynamical behavior, or induce oscillations or chaos. |
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