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Non-imidazole heterocyclic histamine H3 receptor antagonists |
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| Authors: | Chai Wenying Breitenbucher J Guy Kwok Annette Li Xiaobing Wong Victoria Carruthers Nicholas I Lovenberg Timothy W Mazur Curt Wilson Sandy J Axe Frank U Jones Todd K |
| Institution: | Johnson & Johnson Pharmaceutical Research and Development L. L. C., 3210 Merryfield Row, San Diego, CA 92121, USA. wchai@prdus.jnj.com |
| Abstract: | Continued exploration of the SAR around the lead imidazopyridine histamine H(3) antagonist 1 has led to the discovery of several related series of heterocyclic histamine H(3) antagonists. The synthesis and SAR of indolizine, indole and pyrazolopyridine based compounds are now described. |
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