Effect of noradrenaline chronic administration on brown fat phospholipids |
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Authors: | Gérard Mory Myriam Gawer Jean-Claude Kader |
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Institution: | (1) Laboratoire de Physiologie Comparée (URA 307 from CNRS), 4 Place Jussieu, F-75252 Paris Cedex 05, France;(2) Laboratoire de Physiologie Cellulaire (URA 1180 from CNRS), 4 Place Jussieu, F-75252 Paris Cedex 05, France |
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Abstract: | Chronic cold exposure of rats (9 days at 5°C) induces an alteration of the fatty acid composition of phospholipids in brown adipose tissue. The alteration is due to an increase of the unsaturation degree of these lipids. The phenomenon can be reproduced by 10–7 mole. h–1 administration of noradrenaline for 9 days in rats kept at 25°C. Thus, phospholipid alteration in brown fat of cold exposed rats is most probably a consequence of the increase of sympathetic tone which occurs in this tissue during exposure to cold. |
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Keywords: | brown adipose tissue cold-exposure noradrenaline phospholipid unsaturation |
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