| S1P 信号通路：心血管疾病治疗的新靶点 |
| |
| 引用本文： | 孙丽新,梅慧芳,李菡,张陆勇.S1P 信号通路：心血管疾病治疗的新靶点[J].微生物学杂志,2014,38(12). |
| |
| 作者姓名： | 孙丽新 梅慧芳 李菡 张陆勇 |
| |
| 作者单位： | 中国药科大学江苏省新药筛选重点实验室, 江苏 南京210009；中国药科大学药物质量与安全预警教育部重点实验室, 江苏 南京 210009,中国药科大学江苏省新药筛选重点实验室, 江苏 南京210009；中国药科大学江苏省药效研究与评价服务中心, 江苏 南京 210009；,中国药科大学江苏省新药筛选重点实验室, 江苏 南京210009；中国药科大学江苏省药效研究与评价服务中心, 江苏 南京 210009；,中国药科大学江苏省新药筛选重点实验室, 江苏 南京210009；中国药科大学药物质量与安全预警教育部重点实验室, 江苏 南京 210009 |
| |
| 基金项目： | 国家自然科学基金资助项目（No.81274146，No.81102887） |
| |
| 摘 要： | 1- 磷酸鞘氨醇是一种有生物活性的脂质代谢产物，具有调节细胞增殖、再生、迁移，细胞内钙离子移动，黏附分子表达以及激活单核细胞黏附内皮细胞等功效，在血管生理性再生及动脉粥样硬化斑块发生发展中发挥重要作用。1- 磷酸鞘氨醇在高密度脂蛋白中含量在所有脂蛋白中最高，其参与调节高密度脂蛋白的抗氧化、抗血栓、抗炎等效应，而这些反应与1- 磷酸鞘氨醇的生物学功能如血管发生、内皮保护、抑制平滑肌细胞迁移、心肌缺血再灌注损伤的保护等密切相关。对1- 磷酸鞘氨醇信号通路在心血管系统中的作用及以该通路为靶点的相关药物研究进展进行综述，为今后研究提供参考。
|
| 关 键 词： | 1- 磷酸鞘氨醇 心血管疾病 磷酸鞘氨醇受体 FTY720` |
Sphingosine-1-phosphate Signaling Pathway: a Novel Therapeutic Target for Cardiovascular Diseases |
| |
| SUN Lixin,MEI Huifang,LI Han and ZHANG Luyong.Sphingosine-1-phosphate Signaling Pathway: a Novel Therapeutic Target for Cardiovascular Diseases[J].Journal of Microbiology,2014,38(12). |
| |
| Authors: | SUN Lixin MEI Huifang LI Han and ZHANG Luyong |
| |
| Institution: | Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China;Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Ministry of Education, Nanjing 210009, China,Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China;Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing 210009, China;,Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China;Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing 210009, China; and Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China;Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Ministry of Education, Nanjing 210009, China |
| |
| Abstract: | Sphingosine-1-phosphate (S1P) is a pleiotropic lipid metabolite that has been shown to regulate proliferation, regeneration and migration of cells, moving of intracellular calcium ions, expression of adhesion molecules, as well as activation of mononuclear cell adhering to endothelial cells. It plays important roles in vascular physiological regeneration and atherosclerotic plaque development. The level of S1P in highdensity lipoproteins (HDL) is the highest of those in all lipoproteins. S1P can participate in regulating the effects of anti-oxidation, antithrombotic and anti-inflammatory for HDL, which is closely related to S1P biofunctions such as angiogenesis, endothelial protection, inhibition of smooth muscle cell migration, and the protection of myocardial ischemia-reperfusion injury. The research progress in roles of S1P signaling pathway in the cardiovascular system and the related drugs targeting S1P pathway has been reviewed in this paper, so as to provide references for future research. |
| |
| Keywords: | sphingosine-1-phosphate cardiovascular diseases S1P receptor FTY720 |
|
| 点击此处可从《微生物学杂志》浏览原始摘要信息 |
| 点击此处可从《微生物学杂志》下载免费的PDF全文 |
|
