|
|||||
|
|
Synthesis of several chemotactic peptide antagonists |
|
| Authors: | Alan R Day Delia Pinon Natesa Muthukumaraswamy Richard J Freer |
| Institution: | Department of Pharmacology, Medical College of Virginia, Box 613, Richmond, VA 23298, USA |
| Abstract: | The following peptides have been synthesized using classical mixed anhydride methods: Boc-Leu-Phe-OH, Boc-Phe-Leu-Phe-OH, Boc-Leu-Phe-Leu-Phe-OH and Boc-Phe-Leu-Phe-Leu-Phe-OH. The tri, tetra and pentapeptides inhibit Formyl-Met-Leu-Phe-OH induced release of β-glucuronidase from rabbit peritoneal neutrophils. The antagonists exhibit ID50 concentrations in the range 2.6−5.7×10−7M. The dipeptide was inactive at all concentrations tested. |
| Keywords: | Rabbit neutrophils Chemotaxis Antagonists Rapid mixed anhydride coupling Formyl-Met-Leu-Phe-OH |
| 本文献已被 ScienceDirect 等数据库收录！ | |