| 糖尿病伤口愈合的分子机制 |
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| 作者姓名： | Tie L Xiaokaiti Y Wang X Chen AF Li XJ |
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| 基金项目： | 国家自然科学基金,高等学校博士学科点专项科研基金,北京大学中央高校基本科研业务费,* |
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| 摘 要： | 伤口愈合不良是糖尿病的一个并发症,严重时可能导致截肢,已成为糖尿病患者住院率最高的疾病,但是其确切的分子机制尚不清楚。目前研究发现糖尿病发生时有多种分子和细胞功能受损,如生长因子、一氧化氮、活性氧分子、基质金属蛋白酶、m icroRNA、内皮祖细胞等,最终导致糖尿病伤口愈合不良。本文将就其近年研究的相关分子机制予以详述。
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| 关 键 词： | 糖尿病 糖尿病足 伤口愈合 生长因子 一氧化氮 |
Molecular mechanisms of diabetic wound healing |
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| Tie L,Xiaokaiti Y,Wang X,Chen AF,Li XJ.Molecular mechanisms of diabetic wound healing[J].Progress in Physiological Sciences,2010,41(6):407-412. |
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| Authors: | Tie Lu Xiaokaiti Yilixiati Wang Xian Chen Alex F Li Xue-Jun |
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| Institution: | State Key Laboratory of Natural & Biomimetic Drugs and Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, China. |
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| Abstract: | Refractory wound is a severe complication that leads to limb amputation in diabetes, and is also a leading cause of hospitalizations in diabetic patients with limited treatment regimens. However, the underlying mechanisms remain to be fully elucidated. Various factors contribute to delayed diabetic wound healing, such as growth factor, nitric oxide (NO), reactive oxygen species (ROS), matrix metalloproteinases (MMPs), microRNA, endothelial progenitor cells (EPCs), etc. In this review, we will discuss the recent findings on the molecular mechanisms underlying impaired diabetic wound healing. |
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| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ |
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