Antitubercular activity of trifluoperazine, a calmodulin antagonist |
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Authors: | P Ratnakar P Suryanarayana Murthy |
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Institution: | University College of Medical Sciences, Shahdara, Delhi, India. |
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Abstract: | Trifluoperazine, a calmodulin antagonist, completely inhibited the growth of mycobacteria. The minimum inhibitory concentrations in shake cultures in a synthetic medium containing 0.2% Tween 80 were 5 and 8 micrograms/ml, respectively, for the human pathogenic strain Mycobacterium tuberculosis H37Rv and M. tuberculosis resistant to isoniazid. When added to a growing culture of M. tuberculosis H37Rv on the 10th day (mid exponential phase), trifluoperazine 50 micrograms/ml further arrested growth of this organism. It is suggested that trifluoperazine or similar calmodulin antagonists might be useful as antitubercular drugs. |
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Keywords: | Trifluoperazine Calmodulin antagonist Mycobacterium tuberculosis Antitubercular action |
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