Isocyanide-based multicomponent reactions in drug discovery |
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Authors: | Akritopoulou-Zanze Irini |
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Institution: | R4CP, AP10-101, Abbott Laboratories, Abbott Park, IL 60064-6099, USA. irini.zanze@abbott.com |
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Abstract: | This review describes recent advances in the application of isocyanide-based multicomponent reactions (IMCRs) in drug discovery and summarizes the various chemotypes used to probe biological targets. In the past couple of years, IMCR-derived ligands have been used to develop agents against infectious diseases and to interfere with protein-protein interactions. Additionally, they were active against a variety of targets such as enzymes, GPCRs and ion channels. The rational for the chemical biologist to apply such diversity generating chemistries is also discussed. |
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