| 面神经核腹内侧区微量注射三种递质的呼吸效应 |
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| 引用本文： | 张有青,满恒业.面神经核腹内侧区微量注射三种递质的呼吸效应[J].生理学报,1991,43(6):594-599. |
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| 作者姓名： | 张有青 满恒业 |
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| 作者单位： | 山东医科大学生理教研室 济南250012
(张有青，满恒业)，山东医科大学生理教研室 济南250012(刘磊) |
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| 摘 要： | 实验用兔,在乌拉坦静脉麻醉、切断双侧颈迷走神经、自主呼吸条件下进行,以膈神经放电作呼吸指标。观察了面神经核腹内侧区(VMNF)微量注射三种递质对呼吸节律的影响。结果如下:(1)VMNF 区微量注射肾上腺素呼吸频率增加,膈神经吸气性放电的递增速度加快,积分幅度升高,VMNF 区微量注射妥拉苏林,呼吸频率下降且妥拉苏林可阻断肾上腺素的呼吸效应。(2)VMNF 区微量注射γ-氨基丁酸、甘氨酸导致呼吸频率下降,吸气时程、呼气时程延长。提示肾上腺素、γ-氨基丁酸、甘氨酸可能作为递质作用于 VMNF 区的神经元而发挥呼吸调节作用。
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| 关 键 词： | 呼吸 面神经核 腹内侧区 神经递质 |
RESPIRATORY EFFECTS OF MICROINJECTION OF THREE KINDS OF NEUROTRANSMITTERS IN VENTROMEDIAL REGION OF NUCLEUS FACIALIS |
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| ZHANG YOU-QING,MAN HENG-YE,LIU LEI.RESPIRATORY EFFECTS OF MICROINJECTION OF THREE KINDS OF NEUROTRANSMITTERS IN VENTROMEDIAL REGION OF NUCLEUS FACIALIS[J].Acta Physiologica Sinica,1991,43(6):594-599. |
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| Authors: | ZHANG YOU-QING MAN HENG-YE LIU LEI |
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| Institution: | Department of Physiology, Shandong Medical University, Jinan. |
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| Abstract: | The effects of microinjection of three kinds of neurotransmitters in ventromedial region of nucleus facialis (VMNF) on respiration were observed in vagotomized, spontaneously breathing rabbits anesthetized with urethane. Microinjection of adrenaline in VMNF induced a marked increase in respiratory rate and amplitude of integrated phrenic activity associated with an increase in the initial rate of rise of inspiratory activity. However, alpha-receptor antagonist tolazoline elicited marked decreases in respiratory rate accompanied by little or no changes in amplitude of integrated phrenic activity and initial rate of rise of inspiratory activity. The respiratory effects of microinjection of adrenaline were blocked by previous injection of tolazoline. Microinjection of GABA and glycine resulted in a decrease of respiratory frequency. These results suggest that adrenaline, GABA and glycine may modulate respiration by acting on VMNF neurons as neurotransmitters. |
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