Phylogenetic analysis of modularity in protein interaction networks |
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| Authors: | Sinan Erten Xin Li Gurkan Bebek Jing Li and Mehmet Koyutürk |
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| Institution: | (1) Department of Electrical Engineering & Computer Science, Case Western Reserve University, Cleveland, USA;(2) Case Center for Proteomics & Bioinformatics, Case Western Reserve University, Cleveland, USA;(3) Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, USA;(4) Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, USA;(5) Genomic Medicine Institute, Cleveland Clinic, Cleveland, USA |
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| Abstract: | Background In systems biology, comparative analyses of molecular interactions across diverse species indicate that conservation and divergence
of networks can be used to understand functional evolution from a systems perspective. A key characteristic of these networks
is their modularity, which contributes significantly to their robustness, as well as adaptability. Consequently, analysis
of modular network structures from a phylogenetic perspective may be useful in understanding the emergence, conservation,
and diversification of functional modularity. |
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