Structural effects of clinically observed mutations in JAK2 exons 13-15: comparison with V617F and exon 12 mutations |
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| Authors: | Tai-Sung Lee Wanlong Ma Xi Zhang Hagop Kantarjian Maher Albitar |
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| Institution: | (1) Biomedical Informatics and Computational Biology, and Department of Chemistry, University of Minnesota, 207 Pleasant Street, S.E., Minneapolis, MN 55455, USA;(2) Quest Diagnostics Nichols Institute, San Juan Capistrano, California, USA;(3) Department of Leukemia, University of Texas, MD Anderson Cancer Center, Houston, Texas, USA |
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| Abstract: | Background The functional relevance of many of the recently detected JAK2 mutations, except V617F and exon 12 mutants, in patients with
chronic myeloproliferative neoplasia (MPN) has been significantly overlooked. To explore atomic-level explanations of the
possible mutational effects from those overlooked mutants, we performed a set of molecular dynamics simulations on clinically
observed mutants, including newly discovered mutations (K539L, R564L, L579F, H587N, S591L, H606Q, V617I, V617F, C618R, L624P,
whole exon 14-deletion) and control mutants (V617C, V617Y, K603Q/N667K). |
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