The redox protein construction kit: pre-last universal common ancestor evolution of energy-conserving enzymes |
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Authors: | Baymann Frauke Lebrun Evelyne Brugna Myriam Schoepp-Cothenet Barbara Giudici-Orticoni Marie-Thérèse Nitschke Wolfgang |
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Institution: | Laboratoire de Bioénergétique et Ingénierie des Protéines (CNRS UPR 9036), Institut de Biologie Structurale et Microbiologie, 31 chemin Joseph-Aiguier, 13402 Marseille Cedex 20, France. |
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Abstract: | Genome analyses and the resolution of three-dimensional structures have provided evidence in recent years for hitherto unexpected family relationships between redox proteins of very diverse enzymes involved in bioenergetic electron transport. Many of these enzymes appear in fact to be constructed from only a limited set of building blocks. Phylogenetic analysis of selected units from this "redox enzyme construction kit" indicates an origin for several prominent bioenergetic enzymes that is very early, lying before the divergence of Bacteria and Archaea. Possible scenarios for the early evolution of selected complexes are proposed based on the obtained tree topologies. |
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