Extracellular signal-regulated kinase 1/2 plays a pro-life role in experimental brain stem death via MAPK signal-interacting kinase at rostral ventrolateral medulla |
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Authors: | Samuel HH Chan Enya YH Sun Alice YW Chang |
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Institution: | (1) Center for Translational Research in Biomedical Sciences, Chang Gung Memorial Hospital-Kaohsiung Medical Center, 83301 Kaohsiung County, Taiwan |
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Abstract: | Background As the origin of a life-and-death signal detected from systemic arterial pressure, which sequentially increases (pro-life)
and decreases (pro-death) to reflect progressive dysfunction of central cardiovascular regulation during the advancement towards
brain stem death in critically ill patients, the rostral ventrolateral medulla (RVLM) is a suitable neural substrate for mechanistic
delineation of this fatal phenomenon. The present study assessed the hypothesis that extracellular signal-regulated kinase
1/2 (ERK1/2), a member of the mitogen-activated protein kinases (MAPKs) that is important for cell survival and is activated
specifically by MAPK kinase 1/2 (MEK1/2), plays a pro-life role in RVLM during brain stem death. We further delineated the
participation of MAPK signal-interacting kinase (MNK), a novel substrate of ERK in this process. |
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