The DHH1/RCKp54 family of helicases: An ancient family of proteins that promote translational silencing |
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Authors: | Vlad Presnyak Jeff Coller |
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Institution: | Center for RNA Molecular Biology, Case Western Reserve University, Cleveland OH 44106, USA |
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Abstract: | Translational control is a vital aspect of gene expression. Message specific translational repressors have been known for decades. Recent evidence, however, suggests that a general machinery exists that dampens the translational capacity of the majority of mRNAs. This activity has been best ascribed to a conserved family of RNA helicases called the DHH1/RCKp54 family. The function of these helicases is to promote translational silencing. By transitioning mRNA into quiescence, DHH1/RCKp54 helicases promote either mRNA destruction or storage. In this review we describe the known roles of these helicases and propose a mechanistic model to explain their mode of action. This article is part of a Special Issue entitled: The Biology of RNA helicases — Modulation for life. |
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Keywords: | RNA helicase mRNA decay mRNA degradation mRNA translational silencing |
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