Serum hemorphin‐7 levels are decreased in obesity |
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| Authors: | Marie Maraninchi Delphine Feron Ingrid Fruitier‐Arnaudin Audrey Bégu‐Le Corroller Juan P Nogueira Julien Mancini René Valéro Jean M Piot Bernard Vialettes |
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| Institution: | 1. Aix Marseille Université, Inserm, INRA, NORT UMR_1062, Marseille, France;2. APHM, Timone Hospital, Nutrition, Metabolic Diseases and Endocrinology Department, Marseille, France;3. University of La Rochelle, CNRS‐URL, LIENSS UMR 7266, AMES team, Pole of Science and Technology, La Rochelle, France;4. Aix Marseille Université, Inserm, IRD, SESSTIM, UMR 912, Marseille, France;5. APHM, Timone Hospital, Public Health Department, Marseille, France;6. APHM, Timone Hospital, Nutrition, Metabolic Diseases and Endocrinology Department, Marseille, FranceThe first two authors contributed equally to the work. |
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| Abstract: | Objective: Hemorphin peptides exhibit biological activities that interfere with the endorphin system, the inflammatory response, and blood‐pressure control. VV‐hemorphin‐7 and LVV‐hemorphin‐7 peptides exert a hypotensive effect, in particular, by inhibiting the renin–angiotensin system. Furthermore, levels of circulating hemorphin‐7 peptides have been found to be decreased in diseases such as type 1 and type 2 diabetes. Design and Methods: Because type 2 diabetes and obesity share common features, such as insulin resistance, microinflammation, high glomerular‐filtration rate (GFR), and cardiovascular risk, we evaluated serum VV‐hemorphin‐7 like immunoreactivity (VVH7‐i.r.) levels, using an enzyme‐linked immunosorbent assay method, on a group of 54 obese subjects without diabetes or hypertension, compared with a group of 33 healthy normal‐weight subjects. Results: Circulating VVH7‐i.r. levels were significantly decreased in the obese group compared with the control group (1.98 ± 0.19 vs. 4.86 ± 0.54 µmol/l, respectively, P < 0.01), and a significant negative correlation between VVH7‐i.r. and diastolic blood pressure (DBP) was found in obese patients (r = ?0.35, P = 0.011). There was no significant correlation between VVH7‐i.r. level and insulin resistance, metabolic syndrome, or GFR. Conclusions: The decreased serum hemorphin‐7 found in obese subjects, as in diabetes, may contribute to the development of hypertension and to the cardiovascular risk associated with these metabolic diseases. |
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