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Identification of a second Nutlin‐3 responsive interaction site in the N‐terminal domain of MDM2 using hydrogen/deuterium exchange mass spectrometry
Authors:Lenka Hernychova  Petr Man  Chandra Verma  Jude Nicholson  Carrie‐Anne Sharma  Eva Ruckova  Jin Yuan Teo  Kathryn Ball  Borek Vojtesek  Ted R Hupp
Institution:1. Regional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, , Brno, Czech Republic;2. Academy of Sciences of the Czech Republic v.v.i, Institute of Microbiology, , Czech Republic;3. Department of Biochemistry, Faculty of Science, Charles University in Prague, , Prague, Czech Republic;4. Bioinformatics Institute (A*STAR), , Singapore;5. Department of Biological Sciences, National University of Singapore, , Singapore;6. School of Biological Sciences, Nanyang Technological University, , Singapore;7. Cell Signalling Unit, p53 Signal Transduction Laboratories, Institute of Genetics and Molecular Medicine, University of Edinburgh Cancer Research Centre, , Edinburgh, UK
Abstract:
Keywords:Allostery  Biomedicine  Cancer  Deuterium exchange  MDM2  p53
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