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Antioxidant Activity of 5-Hydroxytryptophan, 5-Hydroxyindole, and Dopa Against Microsomal Lipid Peroxidation and Its Dependence on Vitamin E |
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| Authors: | Enrique Cadenas Michael G Simic Helmut Sies |
| Abstract: | The antioxidant capacity of 5-hydroxy-tryptophan. 5-hydroxy-indole. and DOPA (3,4-dihydroxy-phenyI-alanine) was tested in the Fe-induced lipid peroxidation of liver microsomes of normal- and vitamin E-deficient rats, using ascorbate as a reductant. Lipid peroxidation was monitored as low-level chemilu-minescence, indicative of generation of electronically-excited states arising from the recombination of secondary lipid peroxyl radicals. |
| Keywords: | lipid peroxidation vitamin E peroxyl radicals antioxidants low-level chemiluminescence 5-hydroxytryptophan 5-hydroxyindole DOPA or 3 4-dihydroxy-phenylalanine |
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