Genotyping over 100,000 SNPs on a pair of oligonucleotide arrays |
| |
| Authors: | Matsuzaki Hajime Dong Shoulian Loi Halina Di Xiaojun Liu Guoying Hubbell Earl Law Jane Berntsen Tam Chadha Monica Hui Henry Yang Geoffrey Kennedy Giulia C Webster Teresa A Cawley Simon Walsh P Sean Jones Keith W Fodor Stephen P A Mei Rui |
| |
| Affiliation: | Affymetrix, Inc., 3380 Central Expressway, Santa Clara, California 95051, USA. |
| |
| Abstract: | We present a genotyping method for simultaneously scoring 116,204 SNPs using oligonucleotide arrays. At call rates >99%, reproducibility is >99.97% and accuracy, as measured by inheritance in trios and concordance with the HapMap Project, is >99.7%. Average intermarker distance is 23.6 kb, and 92% of the genome is within 100 kb of a SNP marker. Average heterozygosity is 0.30, with 105,511 SNPs having minor allele frequencies >5%. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
