Mesolimbic and striatal dopamine receptor supersensitivity: prophylactic and reversal effects of L-prolyl-L-leucyl-glycinamide (PLG) |
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| Authors: | P Chiu G Rajakumar S Chiu R L Johnson R K Mishra |
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| Institution: | 1. Department of Psychiatry, McMaster University Health Sciences Centre, Hamilton, Ontario L8N 3Z5, Canada;2. Department of Neurosciences, McMaster University Health Sciences Centre, Hamilton, Ontario L8N 3Z5, Canada;3. Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, MN USA |
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| Abstract: | Functional supersensitivity of mesolimbic and striatal dopamine receptors has been suggested to contribute to the pathogenesis of schizophrenia and tardive dyskinesia. Using the rodent model of chronic administration of the neuroleptic haloperidol, we investigated the possible desensitizing effects of a tripeptide structurally unrelated to dopamine agonists, L-prolyl-L-leucyl-glycinamide (PLG) on mesolimbic and striatal dopaminergic receptor supersensitivity. Administration of PLG either prior to or after chronic haloperidol, inhibited the supersensitivity of dopamine receptors. The results have implications for pharmacological intervention in preventing tardive dyskinesia and relapse psychosis of schizophrenia. |
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| Keywords: | PLG Haloperidol Supersensitivity Mesolimbic and striatal dopamine receptors Tardive dyskinesia |
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