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Effect of 8-hydroxyquinoline on the uptake of uridine and incorporation into RNA |
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| Authors: | Donald Grierson Vera Hemleben |
| Affiliation: | (1) Institut für Biologie II, Lehrstuhl für Genetik, Universität Tübingen, Auf der Morgenstelle 28, D-7400 Tübingen, Federal Republic of Germany;(2) Present address: Department of Physiology and Environmental Studies, University of Nottingham, School of Agriculture, Sutton Bonington, LE12 5RD Loughborough, Leicestershire, U.K. |
| Abstract: | 8-hydroxyquinoline has been previously used as an inhibitor in studies on porphyrin metabolism, where it is thought to act by chelating iron. It is shown that this compound also rapidly inhibits uridine uptake of seedlings or cotyledons of the crucifer Matthiola incana R.Br. RNA synthesis is also affected but the inhibition is not as severe as reported for fission yeast.Abbreviations oligo (dT)-cellulose cellulose with oligo-deoxythymidylic acid attached - poly (A) polyadenylic acid |
| Keywords: | RNA synthesis [3H]uridine uptake 8-hydroxyquinoline Matthiola |
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