Foreword: Protein acylation and microdomains in membrane function |
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| Authors: | Anthony I Magee |
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| Institution: | 1. Section of Molecular Medicine, National Heart &2. Lung Institute, Imperial College London, Sir Alexander Fleming Building, South Kensington, London, UKt.magee@imperial.ac.uk |
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| Abstract: | The Signal Recognition Particle (SRP) plays a critical role in the sorting of nascent secretory and membrane proteins. Remarkably, this function has been conserved from bacteria, where SRP delivers proteins to the inner membrane, through to eukaryotes, where SRP is required for targeting of proteins to the endoplasmic reticulum. This review focuses on present understanding of SRP structure and function and the relationship between the two. Furthermore, the similarities and differences in the structure, function and cellular role of SRP in bacteria, chloroplasts, fungi and mammals will be stressed. |
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| Keywords: | Signal recognition particle targeting ribosome GTPase structure/function |
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