Numerical study of the phase separation in binary lipid membrane containing protein inclusions under stationary shear flow |
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| Authors: | Xiao-Bo Chen Hui-Ji Shi Li-Sha Niu |
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| Affiliation: | 1. Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan;2. Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan;3. Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan;4. Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan;5. The Laboratory of Cardiovascular Science in the National Institute on Aging Intramural Research Program in Baltimore, MD, USA;6. Department of Biomedical Engineering, Washington University, St Louis, MO, USA;7. Institute of Public Health, National Yang-Ming University, Taipei, Taiwan;8. Cardiovascular Research Center, National Yang-Ming University, Taipei, Taiwan |
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| Abstract: | The phase separation of lipids is believed to be responsible for the formation of lipid rafts in biological cell membrane. In the present work, a continuum model and a particle model are constructed to study the phase separation in binary lipid membrane containing inclusions under stationary shear flow. In each model, employing the cell dynamical system (CDS) approach, the kinetic equations of the confusion-advection process are numerically solved. Snapshot figures of the phase morphology are performed to intuitively display such phase evolving process. Considering the effects from both the inclusions and the shear flow, the time growth law of the characteristic domain size is discussed. |
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