Effect of inositol hexaphosphate on hemoglobin oxidation by nitrite and ferricyanide |
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| Authors: | Akio Tomoda Shigeru Matsukawa Masazumi Takeshita Yoshimasa Yoneyama |
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| Institution: | 4. Department of Biochemistry, Kanazawa University, School of Medicine Kanazawa Japan 920;1. Department of Medical Technology, Kanazawa University, School of Paramedicine, Kanazawa Japan 920 |
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| Abstract: | In the presence of inositol hexaphosphate (IHP), the rate of hemoglobin oxidation by nitrite was much inhibited; however, that of the hemoglobin oxidation by ferricyanide was much accelerated. The difference in the reaction mode was discussed in relation to the interaction of hemoglobin with IHP. The dissociation constant of IHP to oxyhemoglobin was estimated from the rate of the hemoglobin oxidation by ferricyanide in different concentrations of IHP under oxygen saturated conditions. |
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