| MicroPET观察姜黄素对APPswe/PS1dE9双转基因小鼠脑葡萄糖代谢的影响 |
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| 引用本文： | 王虹,高凯,李瑞晟,任映,朱志慧,孙海芸,杨金铎,王蓬文.MicroPET观察姜黄素对APPswe/PS1dE9双转基因小鼠脑葡萄糖代谢的影响[J].中国实验动物学报,2011,19(4):336-338,I0011. |
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| 作者姓名： | 王虹 高凯 李瑞晟 任映 朱志慧 孙海芸 杨金铎 王蓬文 |
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| 作者单位： | 1. 北京中医药大学东直门医院中药药理学实验室,北京,100700
2. 中国医学科学院医学实验动物研究所,北京,100021 |
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| 基金项目： | 北京市自然基金资助项目(No.7092057); 国家自然基金资助项目(No.81073076) |
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| 摘 要： | 目的利用18氟-脱氧葡萄糖microPET(18F-FDG microPET)影像学技术观察正常对照组小鼠,模型组和姜黄素治疗组APPswe/PS1dE9双转基因小鼠的脑葡萄糖代谢情况。方法随机挑选6月龄正常对照组C57BL/6J小鼠3只,模型组和姜黄素治疗组APPswe/PS1dE9双转基因小鼠各3只,通过2%异氟烷吸入麻醉后,从尾静脉弹丸式注射放射性示踪剂18F-FDG每例约14.8～16.5 MBq,摄取45 min后进行10 min microPET图像采集。计算并比较各组小鼠每克脑组织(除小脑)18F-FDG的摄取率。结果姜黄素治疗组小鼠每克脑组织18F-FDG的摄取率高于正常对照组和模型组。结论姜黄素能明显提高APPswe/PS1dE9双转基因小鼠脑18 F-FDG的摄取及每克脑组织的摄取率,并可能通过影响脑葡萄糖代谢而发挥神经保护作用。
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| 关 键 词： | 18氟-脱氧葡萄糖 脑葡萄糖代谢 姜黄素 APPswe/PS1dE9双转基因小鼠 |
MicroPET observation of the effect of curcumin on cerebral glucose metabolism in APPswe/PS1dE9 double transgenic mice |
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| WANG Hong,GAO Kai,LI Rui-sheng,REN Ying,ZHU Zhi-hui,SUN Hai-yun,YANG Jin-duo,WANG Peng-wen.MicroPET observation of the effect of curcumin on cerebral glucose metabolism in APPswe/PS1dE9 double transgenic mice[J].Acta Laboratorium Animalis Scientia Sinica,2011,19(4):336-338,I0011. |
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| Authors: | WANG Hong GAO Kai LI Rui-sheng REN Ying ZHU Zhi-hui SUN Hai-yun YANG Jin-duo WANG Peng-wen |
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| Institution: | WANG Hong1,GAO Kai2,LI Rui-sheng1,REN Ying1,ZHU Zhi-hui1,SUN Hai-yun1,YANG Jin-duo1,WANG Peng-wen(1.Laboratory of Pharmacology of Traditional Chinese Medicine,Dongzhimen Hospital,BUCM,Beijing 100700,China,2.Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences & Comparative Medical Center,Peking Union Medical College,Beijing 100021,China) |
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| Abstract: | Objective To observe the status of cerebral glucose metabolism in normal control group mice,APP/PS1 double transgenic mice of model group and curcumin treatment group by 18F-FDG microPET.Methods APP/PS1 dtg mice from the model group,curcumin treatment group,and normal C57BL/6J mice with the same background were randomly selected(age: 6 months;n=3)for microPET study.Each mouse was anesthetized using 2% isoflurane and was injected through a tail vein with 14.8-16.5 MBq 18F-FDG as a bolus.After 45-minute of 18... |
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| Keywords: | microPET 18F-FDG Cerebral glucose metabolism Curcumin APPswe/PS1dE9 double transgenic mice |
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