Nerve growth factor antibodies recognize neurotrophin-3 |
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| Authors: | Alessandro Negro Vincenza Corsa Stephen D Skaper Lanfranco Callegaro |
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| Institution: | (1) Advanced Technology Division, FIDIA S.p.A., via Ponte della Fabbrica 3/a, 35031 Abano Terme, Italy;(2) Fidia Research Laboratories, FIDIA S.p.A., via Ponte della Fabbrica 3/a, 35031 Abano Terme, Italy |
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| Abstract: | The immunological properties of the neurotrophins NGF, BDNF, and NT-3 were compared using polyclonal and monoclonal antibodies against the  subunit of mouse NGF. Affinity-purified anti-NGF IgG consistently recognized NGF and NT-3 on Western blots, and inhibited the trophic activity of NGF and NT-3 but not BDNF. In contrast, anti-NGF monoclonal antibodies did not block the trophic activity of either NT-3 or BDNF. These results are consistent with the greater structural overlap between NGF and NT-3 than between NGF and BDNF. |
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| Keywords: | Nerve growth factor brain-derived neurotrophic factor neurotrophin-3 antibody crossreactivity |
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