A cis-Acting Element in Retroviral Genomic RNA Links Gag-Pol Ribosomal Frameshifting to Selective Viral RNA Encapsidation期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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A cis-Acting Element in Retroviral Genomic RNA Links Gag-Pol Ribosomal Frameshifting to Selective Viral RNA Encapsidation

Authors:	Mastooreh Chamanian Katarzyna J Purzycka Paul T Wille Janice S Ha David McDonald Yong Gao Stuart FJ Le Grice Eric J Arts

Institution:	1. Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH 44106, USA;2. RT Biochemistry Section, HIV Drug Resistance Program, National Cancer Institute, Fredrick, MD 21702, USA;3. Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA

Abstract:	Download : Download high-res image (201KB) Download : Download full-size image Highlights? A retroviral RNA packaging element (GRPE) overlaps the Gag-Pol ribosomal frameshift site ? Without two stem loops in GRPE, genomic RNA encapsidation is decreased >50-fold ? Downregulating the translation termination factor eRF1 produces defective virus particles ? GPRE links ribosome frameshifting and effective retroviral packaging

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