Three-dimensional Nuclear Telomere Organization in Multiple Myeloma |
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| Authors: | Ludger Klewes Rhea Vallente Eric Dupas Carolin Brand Dietrich Grün Amanda Guffei Chirawadee Sathitruangsak Julius A. Awe Alexandra Kuzyk Daniel Lichtensztejn Pille Tammur Tiiu Ilus Anu Tamm Mari Punab Morel Rubinger Adebayo Olujohungbe Sabine Mai |
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| Affiliation: | 2. Département de Biochimie, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Québec, Canada;3. University of Dortmund, Dortmund, North Rhine-Westphalia, Germany;4. Division of Medical Oncology, Department of Internal Medicine, Prince of Songkla University Hospital, Hat Yai, Songkla, Thailand;5. United Laboratories, Tartu University Hospital, Tartu, Estonia;11. Physiology, Manitoba Institute of Cell Biology, Winnipeg, Manitoba, Canada |
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| Abstract: | Multiple myeloma (MM) is preceded by monoclonal gammopathy of undetermined significance (MGUS). Up to date, it is difficult to predict an individual's time to disease progression and the treatment response. To examine whether the nuclear telomeric architecture will unravel some of these questions, we carried out. Three-dimensional (3D) telomere analysis on samples from patients diagnosed with MGUS and MM, as well as from patients who went into relapse. Telomere signal intensity, number of telomere aggregates, nuclear volume, and the overall nuclear telomere distribution (a/c ratio) were analyzed. The telomeric profiles allowed for the differentiation of the disease stages. The telomeric profiles of myeloma cells obtained from blood and bone marrow aspirates were identical. Based on this study, we discuss the use of 3D telomere profiling as a potential future tool for risk stratification and personalized treatment decisions. |
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