Associations of protein 4.2 with band 3 and ankyrin |
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Authors: | Yang Su Yu Ding Ming Jiang Weihua Jiang Xiaojian Hu Zhihong Zhang |
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Institution: | (1) Canadian Institutes of Health Research Group in Molecular and Cell Biology of Lipids and Department of Biochemistry, Edmonton, Canada;(2) Health Sciences Laboratory Animal Services, University of Alberta, Edmonton, Alberta, T6G 2S2, Canada;(3) University of Alberta, 327 Heritage Medical Research Centre, Edmonton, AB, T6G 2S2, Canada |
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Abstract: | It was shown previously that the intestinal fatty acid binding protein (I-FABP) is not essential for the absorption of dietary
fat. One notable feature of I-FABP deficiency was the enhancement of body weight gain in male mice but not in female mice.
To explore a possible cause for this gender dimorphic effect, we examined the changes in expression of genes that encode liver
fatty acid binding protein (L-FABP) and ileal lipid binding protein in the small intestine resulting from I-FABP deficiency.
The results indicate that both L-FABP and ilbp levels are modestly increased in the small intestine of chow-fed mice lacking
I-FABP. There was no discernible alteration of overall morphology or histology in the small intestine but changes in liver
histology were evident in I-FABP deficient male mice. Glucose tolerance was also investigated in aged mice. I-FABP deficiency
had no effect on glucose tolerance in male mice but it appeared to be improved in female mice. Thus, male and female mice
clearly respond differently to the loss of I-FABP from the small intestine but the observed changes in the abundance of L-FABP
and ilbp protein do not readily account for this phenomenon. (Mol Cell Boichem xxx: 1–8, 2005) |
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Keywords: | fatty acid binding protein intestine liver |
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