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| 反式激活HIV—1LTR的人疱疹病毒6型（HHV—6）基因片段的初步研究 | |
| 引用本文： | 魏莘 王岱. 反式激活HIV—1LTR的人疱疹病毒6型（HHV—6）基因片段的初步研究[J]. 病毒学报, 1998, 14(4): 370-373 |
| 作者姓名： | 魏莘 王岱 |
| 作者单位： | 南开大学生命科学学院 |
| 摘 要： | 艾滋病（ＡＩＤＳ）主要是由人免疫缺陷病毒（ＨＩＶ）侵入人体后，破坏人的免疫系统造成的。许多流行病学研究已证明，疱疹病毒与ＨＩＶ的共感染可以导致对ＨＩＶ－１启动子的激活，并加速细胞的病理性反应〔１〕，从而加大个体对ＨＩＶ感染的敏感和加快疾病的进程。人疱... |
| 关 键 词： | 人疱疹病毒6型 HHV－6 HIV－1 共转染 |
IDENTIFICATION AND CHARACTERIZATION OF GENE SEGMENTS IN HUMAN HERPESVIRUS 6(HHV-6)B70 FRAGMENT THAT TRANSACTIVATE THE HUMAN IMMUNODEFICIENCY VIRUS 1 PROMOTER |
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| Wei Xin Wang Dai Zhang Li Liu Shuhong Chen Qimin Geng Yunqi. IDENTIFICATION AND CHARACTERIZATION OF GENE SEGMENTS IN HUMAN HERPESVIRUS 6(HHV-6)B70 FRAGMENT THAT TRANSACTIVATE THE HUMAN IMMUNODEFICIENCY VIRUS 1 PROMOTER[J]. Chinese journal of virology, 1998, 14(4): 370-373 | |
| Authors: | Wei Xin Wang Dai Zhang Li Liu Shuhong Chen Qimin Geng Yunqi |
| Abstract: | Human herpesvirus type 6(HHV-6)can transactivate the promoter of human immunodeficiency virus(HIV)and accelerate cytopathogenic effects in HIV infected human T cells. A large 22.25kb fragment B70 of HHV-6 showed high transactivity in vitro. In this study, we demonstrated that 3 subfragments of B70 can transactivate the HIV promoter in cotransfected CV-1 cells. All these subfragments can not transactivate HIV-LTR structure containing a deleted or mutated enhancer. These subfragments can work together to increase the HIV-LTR directed Luc gene expression dramatically. |
| Keywords: | Human herpesvirus 6(HHV-6) Human immunodeficiency virus(HIV) Cotransfection |
| 本文献已被 CNKI 维普 等数据库收录！ | |