Inhibition of mitochondrial ATPase by dicarbopolyborate,a new enzyme inhibitor |
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| Authors: | Zdeněk Drahota Vladislav Mareš Hana Rauchová Patrik Šaf Martin Kalous |
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| Affiliation: | (1) Institute of Physiology, Academy of Sciences, 14200 Prague-4, Czech Republic |
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| Abstract: | Polyborate anions were found to inhibit mitochondrial ATPase. Mercapto and chloro derivatives of dicarbononaborates showed full inhibition of the enzyme activity at 0.5–0.8 mM. The inhibitory effect of dodecaborates was lower. The inhibition was of competitive type with respect to ATP. The inhibition of soluble F1-ATPase indicates a direct interaction of the polyborate anion with the catalytic part of the enzyme molecule. |
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| Keywords: | Polyborate anions mitochondria F0F1-ATPase |
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