| 利用电磁脉冲提高抗癌药物治疗肿瘤细胞疗效的实验研究 |
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| 引用本文： | 曾浩,张弘,王保义,王新民,王子淑,岳碧松,邹方东,耿芹.利用电磁脉冲提高抗癌药物治疗肿瘤细胞疗效的实验研究[J].上海生物医学工程,2003,24(3):23-26. |
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| 作者姓名： | 曾浩 张弘 王保义 王新民 王子淑 岳碧松 邹方东 耿芹 |
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| 作者单位： | [1]四川大学电子信息学院，成都610064 [2]四川大学生命科学学院，成都610064 |
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| 基金项目： | 国家自然科学基金 660 710 2 4 |
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| 摘 要： | 本文采用一种新的方法——电穿孔结合化学药物进行肿瘤治疗的电化学疗法。电穿孔由于能使细胞膜出现瞬时微孔，从而能大大提高癌细胞对药物的吸收率、促进了药物等大分子进入细胞。这里利用电穿孔现象结合抗癌药物治疗昆明小鼠身上的S-180肉瘤，从实验数据可看出，这种方法取得了很好的效果。这种癌症治疗新技术具有易于控制、便于操作等优点，特别适用浅表肿瘤的治疗，为临床治疗肿瘤提供了一条新的途径。
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| 关 键 词： | 电磁脉冲 抗癌药物 药物治疗 癌细胞 电化学疗法 S-180肉瘤 昆明小鼠 |
An Experiment Study of Improving Drug Effect to The Treatment of Tumor by the Electromagnetic Impulse |
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| Zeng Hao,Zhang Hong,Wang Baoyi,Wang Xinmin,Wang Zishu,Yue Bisong Zou Fangdong Geng Qin.An Experiment Study of Improving Drug Effect to The Treatment of Tumor by the Electromagnetic Impulse[J].Shanghai Journal of Biomedical Engineering,2003,24(3):23-26. |
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| Authors: | Zeng Hao Zhang Hong Wang Baoyi Wang Xinmin Wang Zishu Yue Bisong Zou Fangdong Geng Qin |
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| Institution: | Zeng Hao 1 Zhang Hong 1 Wang Baoyi 1 Wang Xinmin 1 Wang Zishu 2 Yue Bisong2 Zou Fangdong2 Geng Qin2 1 Department of Radio Electronics Sichuan University(Chengdu 610064) 2 College of Life Science Sichuan University(Chengdu 610064) |
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| Abstract: | In this paper,we will report a new approach for the treatment of tumor electroporation therapy.Electroporation can greatly enhance the membrane pemeability because it can induce transient pores in cell membranes so it can accelerate molecules like drugs into cytoplasm by transient electromagnetic impulse.We have used the phenomenon of electroporation to treat the S 180 sarcomas of the KunMing mice.From the experiment,we learned this approach could receive remarkable effect.The technique is very easy to control and operate.Especially,it is very effcient to cure the flat tumor.It provided a new approach to cure the tumor in the clinic. |
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| Keywords: | Electroporation Electrochemotherapy(ECT) S 180 Sarcomas Anticancer drug |
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