Segmental homologies in the coding and 3' non-coding sequences of rat liver cytochrome P-450e and P-450b cDNAs and cytochrome P-450e-like genes |
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| Authors: | M Affolter A Anderson |
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| Affiliation: | 1. Centre de recherche sur le cancer de l''Universite Laval, Hotel-Dieu de Quebec Quebec, Quebec, Canada;2. Department de Biologie, Universite Laval, Quebec, Quebec, Canada |
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| Abstract: | The nucleotide sequence of a cloned cDNA insert carried by pHDQ14 was determined and found to code for the 107 C-terminal amino acids of rat liver cytochrome P-450e. Comparison of the pHQ14 cDNA sequence with those of cloned cDNAs for cytochrome P-450b and of 2 P-450e-like genes revealed segmental homologies that may have resulted from gene conversion. These results suggest that gene conversion may generate sequence variants of genes for rat liver cytochrome P-450s. |
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| Keywords: | PB phenobarbital |
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