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A Mechanism of Calmodulin Modulation of the Human Cardiac Sodium Channel
Authors:Christopher N. Johnson  Franck Potet  Matthew K. Thompson  Brett M. Kroncke  Andrew M. Glazer  Markus W. Voehler  Bjorn C. Knollmann  Alfred L. George  Walter J. Chazin
Affiliation:1. Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN 37240, USA;2. Department of Biochemistry, Vanderbilt University, Nashville, TN 37205, USA;3. Department of Chemistry, Vanderbilt University, Nashville, TN 37235, USA;4. Center for Structural Biology, Vanderbilt University, Nashville, TN 37232, USA;5. Center for Arrhythmia Research and Therapeutics, Vanderbilt University, Nashville, TN 37240, USA;6. Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago IL 60611, USA
Abstract:
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  • Keywords:structural biology  solution NMR spectroscopy  X-ray crystallography  small angle X-ray scattering (SAXS)  whole-cell patch-clamp electrophysiology  calcium regulation  cardiac sodium channel (NaV1.5)
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