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Conservation of Dynamics Associated with Biological Function in an Enzyme Superfamily
Authors:Chitra Narayanan  David N. Bernard  Khushboo Bafna  Donald Gagné  Chakra S. Chennubhotla  Nicolas Doucet  Pratul K. Agarwal
Affiliation:1. INRS – Institut Armand-Frappier, Université du Québec, 531 Boulevard des Prairies, Laval, QC H7V 1B7, Canada;2. Genome Science and Technology, University of Tennessee, Knoxville, TN 37996, USA;3. Department of Computational & Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA;4. PROTEO, the Québec Network for Research on Protein Function, Engineering, and Applications, Université Laval, 1045 Avenue de la Médecine, Québec, QC G1V 0A6, Canada;5. GRASP, Groupe de Recherche Axé sur la Structure des Protéines, McGill University, 3649 Promenade Sir William Osler, Montréal, QC H3G 0B1, Canada;6. Computational Biology Institute and Computer Science and Engineering Division, Oak Ridge National Laboratory, 1 Bethel Valley Road, Oak Ridge, TN 37830, USA;7. Department of Biochemistry, Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996, USA
Abstract:
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  • Keywords:enzyme catalysis  protein dynamics  pancreatic-type ribonucleases  superfamily  nuclear magnetic resonance  computer simulations
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