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Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment
Authors:Shawn Xiong  Kristina Lorenzen  Amber L. Couzens  Catherine M. Templeton  Dushyandi Rajendran  Daniel Y.L. Mao  Yu-Chi Juang  David Chiovitti  Igor Kurinov  Sebastian Guettler  Anne-Claude Gingras  Frank Sicheri
Affiliation:1. Lunenfeld-Tanenbaum Research Institute, Sinai Health System, 600 University Avenue, Toronto, ON M5G 1X5, Canada;2. Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada;3. Divisions of Structural Biology and Cancer Biology, The Institute of Cancer Research (ICR), London SW7 3RP, UK;4. Cornell University, Department of Chemistry and Chemical Biology, NE-CAT, Advanced Photon Source, Bldg. 436E, 9700 S. Cass Avenue, Argonne, IL 60439, USA;5. Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada
Abstract:
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  • Keywords:protein kinase  X-ray crystallography  Hippo tumor suppressor pathway  NDR family  kinases  MOB1  FRYL  Furry-like
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