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Long-Lived Folding Intermediates Predominate the Targeting-Competent Secretome
Authors:Alexandra Tsirigotaki  Katerina E Chatzi  Marina Koukaki  Jozefien De Geyter  Athina G Portaliou  Georgia Orfanoudaki  Marios Frantzeskos Sardis  Morten Beck Trelle  Thomas JD Jørgensen  Spyridoula Karamanou  Anastassios Economou
Institution:1. KU Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Molecular Bacteriology, 3000 Leuven, Belgium;2. Institute of Molecular Biology and Biotechnology, FoRTH, University of Crete, 70013 Heraklion, Crete, Greece;3. Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark
Abstract:
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  • Keywords:protein secretion  signal peptide  secretory protein mature domain  targeting  aggregation  folding intermediate  kinetically stalled folding  protein disorder  HDX-MS  molten globule
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