Evidence for the Presence of a Ganglioside Transfer Protein in Brain |
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| Authors: | CM. Gammon R. W. Ledeen |
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| Affiliation: | Departments of Neurology and Biochemistry, Albert Einstein College of Medicine, Bronx, New York, U.S.A. |
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| Abstract: | An extract from rat brain has been shown to catalyze the transfer of ganglioside GM1 from sonicated vesicles to erythrocyte ghosts. It also enhanced the transfer of GM1 to a crude neuronal membrane preparation, whereas myelin took up only a very limited amount. The transfer activity was heat-labile. Similar transfer activities were found in extracts from bovine gray and white matter, that of the former being comparable to rat brain whereas the latter was greater per milligram protein. |
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| Keywords: | Gangliosides Ganglioside transfer protein Neuronal membranes Myelin Red cell membranes |
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