Aporphine and bisaporphine alkaloids from Aristolochialagesiana var. intermedia |
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Authors: | Marcia LR Ferreira Isabele R Nascimento Lucia MX Lopes |
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Institution: | a Instituto de Química, São Paulo State University, UNESP, C.P. 355, 14801-970 Araraquara, SP, Brazil b Departamento de Química, São Carlos Federal University, UFSCar, Via Washington Luiz km 235, C.P. 676, 13565-905 São Carlos, SP, Brazil |
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Abstract: | Corydines, isocorydines, and analogous aporphine alkaloids were isolated from the leaves of Aristolochia lagesiana var. intermedia, together with three bisaporphine salts (lagesianines B-D). Their structures were determined by chemical derivatizations and spectroscopic analyses. Lagesianines B and C are the first examples of N-CH2-N′ and C-2-O-C-1′ linked dimeric aporphine alkaloids, respectively, while the monomeric units of lagesianine D, which has a carbon skeleton, are linked through C-7-C-5′ via an ethane-1,2-diol group (C-7-CHOHCHOH-C-5′). |
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Keywords: | Aristolochia lagesiana var intermedia Aristolochiaceae Alkaloids Aporphine Bisaporphine Alkaloid dimer Lagesianines Corydine Isocorydine Corydine Nα-oxide |
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