A factor analysis model for functional genomics |
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| Authors: | Rafal Kustra Romy Shioda Mu Zhu |
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| Affiliation: | (1) Public Health Sciences, Health Sciences Bldg, University of Toronto, Toronto, ON, Canada;(2) Department of Combinatorics and Optimization, University of Waterloo, Waterloo, ON, Canada;(3) Department of Statistics and Actuarial Science, Universityof Waterloo, Waterloo, ON, Canada |
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| Abstract: | ![]()
Background Expression array data are used to predict biological functions of uncharacterized genes by comparing their expression profiles to those of characterized genes. While biologically plausible, this is both statistically and computationally challenging. Typical approaches are computationally expensive and ignore correlations among expression profiles and functional categories. |
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