| 一株广谱中和抗原性出血热病毒株的发现 |
| |
| 引用本文： | 俞永新 何浩. 一株广谱中和抗原性出血热病毒株的发现[J]. Virologica Sinica, 1991, 6(3): 271-273 |
| |
| 作者姓名： | 俞永新 何浩 |
| |
| 作者单位： | 中国药品生物制品检定所，中国药品生物制品检定所，中国药品生物制品检定所，安徽医学科学研究所，浙江省卫生防疫站 北京 100050，北京 100050，北京 100050，合肥，杭州 |
| |
| 摘 要： | 一株分离自杭州市褐家鼠的出血热病毒Gou_3株的免疫血清对10株I型病毒的中和滴度除二株为160外均为320,而对4株Ⅱ型病毒的滴度为320—640,说明Gou_3株免疫血清对两型毒株中和效价大多数无差异或只差2倍,是一株中和抗原广谱的毒株。用I型和Ⅱ型毒株免疫血清对Gou_3株进行型别检定结果表明Gou_3株是Ⅱ型病毒。
|
| 关 键 词： | 流行性出血热病毒株 中和抗原 空斑减少 中和试验 |
Discovery and Study of a Neutralizing Antigen Broad HFRS Virus Strain Gou3 |
| |
| Yu Yong-xin An Qi Yao Zhi-hui He Hao Zhu Zhi-yong#. Discovery and Study of a Neutralizing Antigen Broad HFRS Virus Strain Gou3[J]. 中国病毒学(英文版), 1991, 6(3): 271-273 |
| |
| Authors: | Yu Yong-xin An Qi Yao Zhi-hui He Hao Zhu Zhi-yong# |
| |
| Affiliation: | Yu Yong-xin An Qi Yao Zhi-hui He Hao~* Zhu Zhi-yong~# |
| |
| Abstract: | Antigenicity of a HFRS virus strain, Gou_3, isolated from Rattus norvegicus, was studied by plaque reduction neutralization test. Anti-Gou_3 rabbit serum was used for neutralization with ten Type 1 HFRS viruses and_4 Type 2 viruses. The results revealed that anti-Gou_3 serum reacted to almost the same of neutralizing titer with most of the virus strains in both types, indicating that Gou_3 is a neutralizing antigen broad virus strain. This is the first discovery and it is of significance in selection of seeds for vaccine production. |
| |
| Keywords: | Hemrrhagic Fever with Renal Syndrome Virus Neutralizing antigen Plaque reduction neutralization test |
| 本文献已被 CNKI 维普 等数据库收录！ |
