| 外阴皮肤营养不良组织中人乳头瘤病毒DNA的检测 |
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| 引用本文： | 张利宁,盖其伟,等.外阴皮肤营养不良组织中人乳头瘤病毒DNA的检测[J].Virologica Sinica,1991,6(4):304-308. |
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| 作者姓名： | 张利宁 盖其伟 |
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| 作者单位： | 山东医科大学电镜室，山东医科大学电镜室，首都医学院电镜室，山东医科大学电镜室，首都医学院电镜室 济南 250012，济南 250012，北京 100054，济南 250012，北京 100054 |
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| 摘 要： | 采用Southern Blot分子杂交方法检测了9例外阴皮肤营养不良组织中人乳头瘤病毒DNA的存在情况。结果显示8例增生型营养不良组织中,2例HPV-16阳性,1例HPV33阳性,在3例组织中探测到HPV16相关序列,在1例混合型中也检测到HPV16相关序例,HPV DNA的总检出率为77％。结果提示外阴皮肤营养不良的发生可能与HPV感染有关。
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| 关 键 词： | 核酸分子杂交 人乳头瘤病毒 外阴皮肤营养不良症 |
Detection of Human Papillomavirus DNA from Epithelial Lessions of Vulvar Dystrophies by lsotope-labelled DNA Probes |
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| Zhang Li-ning et al.Detection of Human Papillomavirus DNA from Epithelial Lessions of Vulvar Dystrophies by lsotope-labelled DNA Probes[J].中国病毒学(英文版),1991,6(4):304-308. |
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| Authors: | Zhang Li-ning |
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| Abstract: | Vulvar biopsy specimens from nine patients with vulvar dystrophy were examined for the presence of human papillomavirus DNA by Southern blot hybridization. The results showed that two of eight hypcrplastic dystrophies contained HPV 16 homologous sequence, one contained HPV 33 homologous sequence and three cases were positive for HPV relative sequence HPV relative sequence was also detected in one case with mixed dystrophy. So total proportion of HPV in the nine vulvar specimens was seventy seven percent, The result suggested that the genesis of vulvar dystrophy may be related to infection of HPV. |
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| Keywords: | Molecular Hybridization of Nucleic Acid Human Papillomvirus Vulvar dystrophy |
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