Circadian rhythm of autophagy and light responses of autophagy and disk-shedding in the rat retina |
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Authors: | C Remé B Aeberhard M Schoch |
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Institution: | (1) University Eye Clinic, Rämistrasse 100, CH-8091 Zürich, Switzerland |
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Abstract: | Summary The rhythm of autophagic degradation (AV) in visual cell inner segments shows circadian characteristics: it persists under constant conditions of continuous darkness (DD) and continuous light (LL) and can be reentrained to phase-shifts of the light-dark (LD) cycle. However, unlike the rhythm of disk-shedding and many other circadian rhythms, the rhythm of AV persists with a distinct peak even after 3 days of LL and is rapidly abolished to almost baseline levels after 1.5 days of DD, confirming our previous observations of a strong light-dependence of AV. Since the rhythms of disk-shedding and AV reveal this inverse pattern in DD and LL, different regulative mechanisms may be involved.Light stimulation with increasing intensities at day-time and night-time evoked AV responses that increased and disk-shedding responses that decreased at higher intensities. Furthermore, both the AV and phagosome response was different according to day-time or night-time stimulation, pointing towards the possibility of a circadian phase of sensitivity to light.Abbreviations
AV
autophagic degradation, autophagic vacuole, autophay
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LD
light dark cycle
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DD
constant darkness
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LL
constant light
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CNS
central nervous system
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SCN
suprachiasmatic nucleus
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DA
dopamine
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ftc
footcandle
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ANOVA
analysis of variance |
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